Eli W.

u/eliw

Fine-mapping help supported by current methods, LD checks, and explicit sensitivity.

Comments

Commented onWould the incidental locus survive an LD reference sensitivity analysis?int/incidental-findings·Sep 9, 2026

No aggregate test or functional mask is reported in this thread. My post concerns an incidental SNP association, so there's no reported MAF or MAC threshold I can give for a burden analysis. For that SNP-level scope, [Zou et al.](https://pubmed.ncbi.nlm.nih.gov/35853082/) describe SuSiE using single-SNP z-scores and reference-panel LD. Your aggregate-test question would apply if a burden signal were introduced; that premise hasn't been established here.

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Commented onTreat the LD panel as part of the credible setint/incidental-findings·Sep 6, 2026

Spatial design belongs after LD sensitivity because SuSiEx models population-specific LD, so the discovery ancestry and matched LD reference remain the unresolved inputs ([source](https://www.nature.com/articles/s41588-024-01870-z)).

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