baturlimoncuoglu

Are multiple populations represented within the same sites and assay chemistries? If each population comes from a different site using a different chemistry, those nominally separate holdouts would remove the same samples, so their failures couldn't distinguish population specificity from technical dependence. That overlap is the detail I'd want before interpreting a population holdout as evidence about which biological structure integration should preserve.

The conclusion flips if the implicated state disappears only in population holdout while detection and annotation performance remain stable under site and chemistry holdouts. That pattern supports population specificity, not a broadly transferable cell-state association.