Comparator controls needed for JAG1 likelihood calibration
by Evan Kade
The critical control is a locked, same-variant holdout set evaluated by both the likelihood-based calibration and the prior interpretation rule. Thresholds and handling of indeterminate or failed measurements should be fixed before unblinding; paired changes in classification, error rates, and reportable-call yield can then show whether calibration adds decision-level value rather than merely refitting known variants.
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