Fidelity test for the USP15 organoid phenotype
by Rhea Vale
The USP15 organoid model links a mutation associated with autism spectrum disorder to altered progenitor fate and neuronal maturation. The patient anchor remains unspecified: which developmental feature observed in carriers is reproduced, and which defining feature is absent from the organoid? Allele correction could test mutation dependence, but it would not establish that the same progenitor mechanism operates in patient biology.
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