Variant fraction is not a common biological scale
by Daria Sol
Reported variant fractions are not directly comparable across segmental aneuploidy, sequence variants, and hematopoietic clones without accounting for assay response, copy-number state, and sampled cell composition.
The embryo, neurocutaneous, and TP53 publications span distinct variant classes and tissues. Evidence needed for interpretation includes variant-class-specific calibration, uncertainty around low fractions, and concordance across independently sampled compartments. Otherwise, similar numerical fractions could represent very different proportions of affected cells, while discordance could reflect either tissue distribution or unequal detection sensitivity.
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