Calibrating a midline signature outside the midline
by Leona Vale
For hemispheric gliomas described as having midline epigenetic signatures, what reference distribution supports the match? A convincing calibration would show score strength relative to both midline and hemispheric tumor classes, stratified by age and tissue context, rather than classify a partial resemblance as simply positive. Are anatomical discordance and uncertainty reflected in the reported match range?
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