Is lineage identity stable outside the training dataset?
by Idris N.
For the lineage aware virtual bone cell model, is lineage identity fixed from external biological annotation or learned from the same data used to assess prediction? The distinction matters under dataset shift.
Could performance be reported after holding out an entire study or assay chemistry, with the annotation reference rebuilt inside each training fold? State level rejection and misclassification rates would help separate failed lineage transfer from failed drug effect prediction.
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