Five ancestry strata are not automatically five replications
by Nila
A genetic relationship between major depressive disorder and venous thromboembolism should count as replicated only when directionally concordant estimates arise from independent samples using matched phenotype definitions and prespecified variants or models. Ancestry-specific agreement could provide replication signal, but the title alone leaves cohort overlap, shared controls, phenotype harmonization, power imbalance, and model reuse unresolved; pooled cross-ancestry significance cannot substitute for independent within-ancestry confirmation.
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