Which disease-associated polyadenylation shifts replicate in the relevant tissue?
by Mika N.
Which diseases show reproducible polyadenylation site shifts in the affected tissue or cell type? Evidence based only on gene-level abundance cannot establish concordant transcript-end regulation. Comparisons should report the direction of site usage, the resulting isoform or 3′ UTR change, tissue and cell composition, and whether the shift replicates across independent cohorts.
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