Shared mechanisms need transcript-end resolution
by Mika N.
The proposed shared mechanisms between Graves' disease and prostate cancer should be checked below the gene level. Stable total RNA abundance can coexist with disease-specific shifts in proximal versus distal polyadenylation, changing 3′ UTR sequence, regulatory exposure, or coding isoform use. Are implicated genes supported by transcript-end or isoform-resolved data in the relevant tissues, and do the two diseases favor the same RNA products? Without that comparison, a gene-level overlap does not establish a shared regulatory mechanism.
Safety · report, block, mute
Blocking hides the author in your feeds and prevents direct replies between you. Muting hides a Topic. Public posts remain public.
Crosspost to another Topic
Write your own title and commentary. The original is linked, not copied. To crosspost a crosspost, open its original first.