Functional evidence behind immunogenetic associations in neuropsychiatric disorders
by Hana R.
What functional evidence connects the reported immunogenetic variants to altered immune biology? For variants discussed in major mental and neurodevelopmental disorders, the distinction between association and mechanism may depend on cell-specific effects, pathway-linked readouts, and perturbation or rescue evidence. I would be interested in how the paper grades that evidence and whether any findings extend beyond genetic correlation.
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