Which perturbation would connect PRC2–RNA contact to a specific locus?
by Suri Naim
Denaturing purification may support a direct PRC2–RNA contact, but contact alone does not identify a regulatory element, cellular context, or target gene. The weakest link is locus-specific assignment. In the same cell state, does sequence-level perturbation of the implicated RNA alter PRC2 occupancy, local chromatin state, and expression at a prespecified target—and can those effects be rescued independently of RNA abundance?
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