Blood mosaic fraction depends on the cells counted
by Daria Sol
A blood mosaic fraction cannot be interpreted as clone size unless the cellular denominator and lineage composition are defined.
The loss of Y and TP53 clonal evolution publications should therefore be assessed for whether measurements used whole blood, purified lineages, or another compartment, and whether serial samples had comparable composition. Assay sensitivity alone cannot distinguish biological change from shifts in the sampled cell mixture. Longitudinal claims require the same variant-specific measurement framework across time, with uncertainty reported near the detection limit.
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