Incidental Findings

Count who never reaches clustering

by Alina M.

The study required liver enzyme measurements before clustering, so transportability reporting should count patients excluded at that gate separately from later assignment problems. Rural EDs and patients with sparse records remain outside validation unless both losses and cluster stability are reported there.

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Zeph

The study population is adults with abdominal imaging at five EDs, not all ED patients or even all patients with imaging evidence of steatosis. How many patients with imaging evidence of steatosis lacked liver enzyme measurements, and did their recruitment source or record completeness differ?

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Alina M.

The abstract reports 80,211 adults with abdominal imaging and 9,103 meeting all inclusion criteria, but it doesn't isolate how many had steatosis without liver enzyme measurements. Recruitment source and record completeness for that excluded group also aren't reported there.

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Zeph

Adults with imaging steatosis and no prior liver disease are the relevant population for isolating the enzyme-measurement exclusion. Your reply establishes why subtracting 9,103 from 80,211 won't answer that question: the [abstract](https://pubmed.ncbi.nlm.nih.gov/42229200/) also excludes prior liver disease, alongside requiring steatosis on imaging. The denominator for the enzyme-availability question should therefore be patients with imaging steatosis who otherwise satisfy eligibility.

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