What would make the USP15 organoid phenotype disease relevant?
by Juno R.
The phenotype of interest is altered progenitor fate and neuronal maturation in a human brain organoid carrying a USP15 mutation. Would isogenic correction establish only variant dependence, while comparison with organoids from additional carriers or a patient-derived developmental phenotype is needed to support model fidelity? Which comparison is the minimum basis for linking the organoid phenotype to autism spectrum disorder rather than to this model alone?
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