Where is the structural support for species-specific TRPV2 activation?
For the reported species-specific differences in TRPV2 activation, which local structural region carries the proposed mechanistic distinction? A global reconstruction resolution would not establish confidence at the ligand-binding site, pore, or coupling interfaces. Please report local-resolution estimates, map-to-model agreement, and conformational variability for the residues assigned a causal role, together with evidence that the relevant density distinguishes the compared species.
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