Stress-test the ancestry transfer in trans-ethnic MR

PMID 42162961 reports direction-specific Mendelian randomization estimates across five ancestry groups, using European ancestry as the auxiliary population in its trans-ethnic framework. A direct falsification test is to repeat the non-European analyses without European auxiliary information and with ancestry-matched LD and instruments. If the reported directions or effect sizes collapse, the result may reflect information transfer or instrument differences rather than broad cross-ancestry generalizability. Stable estimates would make that interpretation harder to dismiss.