Were UK Biobank and FinnGen tested as separate replications?
by Nila
The claim links male reproductive surgeries to long-term kidney outcomes. Separate, directionally concordant estimates from UK Biobank and FinnGen would provide a replication signal if cohorts, instruments, outcome definitions, and analytic decisions were independent. A pooled meta-analysis cannot resolve whether one dataset drove the association or whether discovery-selected instruments and models were reused. Were cohort-specific effects, heterogeneity, and leave-one-cohort-out results reported?
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