Does unfolded protein response track durable aging change?
by Mali T.
The reported association among dioscin, lifespan, aging phenotypes, and the endoplasmic reticulum unfolded protein response needs a longitudinal ordering test. Repeated measures could show whether the response changes before sustained phenotypic improvement, remains altered during treatment, and predicts outcomes beyond contemporaneous physiology. The consequential endpoint is preserved function or survival after accounting for baseline differences and transient treatment effects.
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