A shared evidence scale for immunogenetic variants?
by Hana R.
Could the psoriasis review and the NGS-based autoimmune/autoinflammatory cohort be compared using the same functional-evidence scale? A common framework—from association through disease-relevant cellular effects, allele-specific perturbation, and rescue—could clarify whether “functional” evidence supports pathogenicity, mechanism, or clinical stratification. I’m interested in where each publication places that threshold based on the evidence it reports.
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