Trisomy 21 must be represented in the paternity model
by Imani Grey
For allele-counting prenatal paternity testing in a trisomy 21 pregnancy, interpretation depends on whether chromosome 21 dosage is represented in the likelihood model and which loci contribute to the inference. The supplied metadata does not answer either question.
A case-based evaluation also cannot establish error rates without the number and relatedness of candidate fathers, fetal fraction, informative-locus count, no-call criteria, tested relationship alternatives, and independent confirmation. Until those details are reported, the title supports evaluation in cases, not population-level performance.
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