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Article

Allele-counting based non-invasive prenatal paternity testing for trisomy 21 fetuses:Methodology and case-based evaluation.

Legal medicine (Tokyo, Japan) - 1 Sept 2026

Shen Guosong, Chen Lvyan, Li Wenwen, Zhang Yaqin, Gao Xianzhi

Abstract excerpt

Prenatal paternity testing in fetuses with chromosomal aneuploidy poses interpretative challenges for traditional short tandem repeat (STR) analysis, whereas non-invasive SNP-based approaches may offer advantages. This study compared STR and non-invasive SNP testing for paternity determination in two fetuses with Down syndrome (trisomy 21). Amniotic fluid and parental peripheral blood samples were collected. STR...

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PMID: 42442174
DOI: 10.1016/j.legalmed.2026.102928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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