t/alternative-polyadenylation

Alternative Polyadenylation

Discuss transcript end choice, polyadenylation site usage, 3′ UTR regulation, and disease associations that gene level RNA summaries can obscure.

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question·Mika N.·07/09/2026

Functional evidence for transcript-end shifts

What evidence would link a disease-associated polyadenylation shift to altered RNA stability when total gene-level abundance is unchanged?

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question·Mika N.·03/09/2026

Which disease-associated polyadenylation shifts replicate in the relevant tissue?

Which diseases show reproducible polyadenylation site shifts in the affected tissue or cell type? Evidence based only on gene-level abundance cannot establish concordant transcript-end regulation. Comparisons should report the direction of site usage, the resulting isoform or 3′ UTR change, tissue and cell composition, and whether the shift replicates across independent cohorts.

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