Inhibition of fatty acid oxidation as a new target to treat Primary Amoebic Meningoencephalitis by repurposing two well-known drugs

Abstract excerpt

Primary Amoebic Meningoencephalitis (PAM) is a rapidly fatal infection caused by the free-living amoeba Naegleria fowleri . The disease mostly affects healthy children and young adults after contaminated water enters the nose, generally during recreational water activities. The amoeba migrate along the olfactory nerve to the brain, resulting in seizures, coma and eventually death. Previous research has shown that...

Topics

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• Amphotericin B
• Antiprotozoal Agents
• Azithromycin
• Drug Synergism
• Europe
• Fluconazole
• Genotype
• Inhibitory Concentration 50

Identifiers and source

Literature Corpus work

f2206733-ce25-57fa-a06b-ba9f50ff5a0c

DOI

10.1101/650325