Back to search

Article

Modulating SPARC Expression in Mesenchymal Stem Cells Improves Secretome-Mediated Skin Regeneration and Wound Repair

2026-03-09

Abstract excerpt

<h4>ABSTRACT</h4> Mesenchymal stem cells (MSCs) have garnered significant attention over the past three decades due to their robust regenerative potential, primarily mediated by their paracrine activity by releasing soluble bioactive factors and extracellular vesicles (EVs). The MSC secretome plays a pivotal role in wound healing by influencing cellular migration, inflammation, angiogenesis, extracellular matrix...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
cfc231ef-a118-513e-b9a6-f186614bf358
DOI
10.64898/2026.03.07.710278
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Modulating SPARC Expression in Mesenchymal Stem Cells Improves Secretome-Mediated Skin Regeneration and Wound RepairDOI 10.64898/2026.03.07.710278
Small Extracellular Vesicles from Human Bone Marrow Mesenchymal Stromal Cells enhance migration and regulate gene expression of reparative mechanisms in human dermal fibroblastsSemantic proximity
Niche interactions in epidermal stem cellsSemantic proximity
Transcriptomic Landscape and Functional Characterization of Human Induced Pluripotent Stem Cell-Derived Limbal Epithelial Progenitor CellsSemantic proximity
Comprehensive RNA sequencing in primary murine keratinocytes and fibroblasts identifies novel biomarkers and provides potential therapeutic targets for skin-related diseasesSemantic proximity
Advances in microRNA from adipose-derived mesenchymal stem cell-derived exosome: focusing on wound healingSemantic proximity
Global signatures of the human mesenchymal stromal cell secretome: A comparative proteomic analysis of iPSC and tissue-derived MSC secretomes before and after inflammatory licensingSemantic proximity
MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysisSemantic proximity
Improving dermal fibroblast-to-epidermis communications and aging wound repair through extracellular vesicle-mediated delivery of Gstm2 mRNASemantic proximity
mRNA profiling of mesenchymal stem cell-derived exosomes reveals their function in accelerating wound healingSemantic proximity
Stem cells of the skin epitheliumSemantic proximity
An advanced ADSC therapy for keloid prevention using identification of functional subgroups by single cell transcriptomic analysisSemantic proximity
Characterizing the secretome of licensed hiPSC-derived MSCsSemantic proximity
Select a neighboring publication to make it the new centre.