Article

Modeling the dynamics of within-host viral infection and evolution predicts quasispecies distributions and phase boundaries separating distinct classes of infections

2021-12-20

Abstract excerpt

We use computational modeling to study within-host viral infection and evolution. In our model, viruses exhibit variable binding to cells, with better infection and replication countered by a stronger immune response and a high rate of mutation. By varying host conditions (permissivity to viral entry T and immune clearance intensity A ) for large numbers of cells and viruses, we study the dynamics of how viral p...

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Identifiers and source

Literature Corpus work: cbb0286e-9a09-5d0b-ac66-058fcd26879c
DOI: 10.1101/2021.12.16.473030

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