Factors secreted by monosodium urate crystal-stimulated macrophages promote a proinflammatory state in osteoblasts: a potential indirect mechanism of bone erosion in gout

Abstract excerpt

<h4>Background: </h4> Tophi are lesions commonly present at sites of bone erosion in gout-affected joints. The tophus comprises a core of monosodium urate (MSU) crystals surrounded by soft tissue that contains macrophages and other immune cells. Previous studies found that MSU crystals directly reduce osteoblast viability and function. The aim of the current study was to determine the indirect, macrophage-mediated...

Topics

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• Caspase 1
• Crystallization
• Dose-Response Relationship, Immunologic
• Inflammation Mediators
• Interleukin-1beta
• Lipopolysaccharides
• NLR Family, Pyrin Domain-Containing 3 Protein
• Uric Acid

Identifiers and source

Literature Corpus work

ca35e46b-3f35-511f-8c7f-855554206150

DOI

10.21203/rs.3.rs-1686884/v1