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Article

Genomic rearrangements at the BRCA1 locus in Spanish families with breast/ovarian cancer.

Clinical chemistry - 1 Aug 2006

de la Hoya Miguel, Gutiérrez-Enríquez Sara, Velasco Eladio, Osorio Ana, Sanchez de Abajo Ana, Vega Ana, Salazar Raquel, Esteban Eva, Llort Gemma, Gonzalez-Sarmiento Rogelio, Carracedo Angel, Benítez Javier, Miner Cristina, Díez Orland, Díaz-Rubio Eduardo, Caldes Trinidad

Abstract excerpt

BACKGROUND: Large genomic rearrangements (LGRs) account for a substantial proportion of the BRCA1 disease-causing changes, or variations, identified in families with hereditary breast/ovarian cancer [HB(O)C]. Great differences in the spectrum and prevalence of BRCA1 LGR have been observed among p...

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Source

Identifiers

PMID: 16793929
DOI: 10.1373/clinchem.2006.070110

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16793929-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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