MicroRNA inhibition using antimiRs in acute human brain tissue sections

Abstract excerpt

<h4>Introduction</h4> An emerging pre-clinical approach for the treatment of pharmacoresistant epilepsy is targeting the microRNA (miRNA) system. MiRNAs are short noncoding RNAs that suppress gene expression at the post-transcriptional level. Targeting miRNAs, which is possible using antisense oligonucleotide ‘antimiRs’ can produce broad effects on gene expression suited to the complex pathophysiology in temporal...

Topics

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• Blood-Brain Barrier
• Disease Management
• Disease Susceptibility
• Epilepsy
• Gene Silencing
• Gene Transfer Techniques
• Genetic Therapy
• RNA Interference

Identifiers and source

Literature Corpus work

be809dcd-9758-5b08-a71a-fb514dc6d398

DOI

10.1101/2022.04.05.487136