Article

Ectopic overexpression of GRK5 promotes malignant glioma progression closely associated with MSN-CD44 expression and glioma localization

2022-11-28

Abstract excerpt

<h4>Background: </h4> Gliomas are highly invasive and lack of effective targeted therapy. GRK5 is involved in several pathologic conditions including cancer. GRK5 phosphorylated MSN on T66 and regulated the subcellular distribution of MSN, which was a glioma progression marker that induces proliferation via interaction with CD44. Therefore, targeting GRK5-MSN-CD44 may provide a novel approach for the treatment of...

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Literature Corpus work: bce3e241-f7b0-5c20-84a3-276236806d9e
DOI: 10.21203/rs.3.rs-2250776/v1

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