1-Piperidine Propionic Acid Ameliorates Experimental Crystal-induced Arthritis and Carrageenan-induced Hyperalgesia

Abstract excerpt

<title>Abstract</title> <p>Objective Musculoskeletal diseases, particularly arthritis, are a leading cause of disability worldwide. Current treatments have limitations, prompting the search for new therapeutic targets. This study investigated the anti-inflammatory and analgesic effects of 1-Piperidine Propionic Acid (1-PPA), a novel proteinase-activated receptor-2 (PAR2) antagonist, in two mouse models of joint...

Topics

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• Anti-Inflammatory Agents
• Inflammasomes
• Macrophages
• MicroRNAs
• NF-kappa B
• NLR Family, Pyrin Domain-Containing 3 Protein
• STAT3 Transcription Factor
• Uric Acid

Identifiers and source

Literature Corpus work

8db953ac-bc21-5214-b8b2-13ebcb3d4bc4

DOI

10.21203/rs.3.rs-8581656/v1