Article

Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1

2021-06-19

Abstract excerpt

The actin motor protein myosin VI is a multivalent protein with diverse functions. Here, we identified and characterised a myosin VI ubiquitous interactor, the oral-facial-digital syndrome 1 (OFD1) protein, whose mutations cause malformations of the face, oral cavity, digits, and polycystic kidney disease. We found that myosin VI regulates the localisation of OFD1 at the centrioles and, as a consequence, the recru...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 857c55cc-02d7-5872-9e4a-bdf91b7c478e
DOI: 10.1101/2021.06.18.448975

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1DOI 10.1101/2021.06.18.448975Read

The molecular basis of oral-facial-digital syndrome, type 1.Semantic proximity Read

OFD Type I syndrome: lessons learned from a rare ciliopathy.Semantic proximity Read

OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar satellites and centrosomes and is mutated in one individual with oral-facial-digital syndrome.Semantic proximity Read

Functional characterization of the OFD1 protein reveals a nuclear localization and physical interaction with subunits of a chromatin remodeling complex.Semantic proximity Read

A ciliopathy complex builds distal appendages to initiate ciliogenesisSemantic proximity Read

Truncating mutations in exons 20 and 21 of OFD1 can cause primary ciliary dyskinesia without associated syndromic symptomsSemantic proximity Read

The ciliogenic protein Oral-Facial-Digital 1 regulates the neuronal differentiation of embryonic stem cells.Semantic proximity Read

OFD1: One gene, several disorders.Semantic proximity Read

Micrognathia in mouse models of ciliopathies.Semantic proximity Read

Functional characterization of tektin-1 in motile cilia and evidence for TEKT1 as a new candidate gene for motile ciliopathies.Semantic proximity Read

Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specificationSemantic proximity Read

IK is essentially involved in ciliogenesis as an upstream regulator of oral-facial-digital syndrome ciliopathy gene,ofd1Semantic proximity Read