Diet-responsive proteogenomic effects following short-term restriction of animal products in humans.

doi:10.1038/s41467-026-76379-6

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Article

Diet-responsive proteogenomic effects following short-term restriction of animal products in humans.

Nature communications - 8 Aug 2026

Simistiras Alexandros, Bocher Ozvan, Emmanouil Christina, Skoulakis Anargyros, Glentis Stavros, Scarmeas Nikolaos, Zeggini Eleftheria, Rouskas Konstantinos, Dimas Antigone S

Abstract excerpt

The effect of diet on genetic regulation in humans remains largely unexplored. Here, we investigate gene-diet interactions in a unique group of healthy individuals (N = 200) who alternate between omnivory and dietary restriction of animal products for religious reasons. Using longitudinal proteomic and genotype data, we identify diet-responsive cis-pQTLs and highlight regulatory effects on LBR and MSRA, proteins...

Read the complete abstract on PubMed

Topics

Humans
Female
Male
Animals
Proteogenomics
Quantitative Trait Loci
Fibroblast Growth Factors
Diet
Obesity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Seasons

Polymorphism, Single Nucleotide

Gene Expression Regulation

Genotype

Cholesterol

Source

Open in PubMed

Identifiers

PMID: 42706243
DOI: 10.1038/s41467-026-76379-6

Genes

LBR
CASP3
FGF21
IL12RB1
MAVS
MSRA
PDLIM7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.