Article

CF Screening Efficacy and Seasonal Variation in California: 15-Year Comparison of IRT Cutoffs Versus Daily Percentile for First-Tier Testing

2024-09-29

Abstract excerpt

The California Genetic Disease Screening Program (GDSP) employs a fixed immunoreactive trypsinogen (IRT) cutoff followed by molecular testing to screen newborns for Cystic Fibrosis (CF). The cutoffs approximate a 1.6% yearly IRT screen positive rate, however seasonal variation in IRT population means led us to develop a model to establish fixed IRT cutoffs that anticipate seasonal variation and minimize missed cas...

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Literature Corpus work: 5532644d-4446-5842-a96d-1cae86c8464b
DOI: 10.20944/preprints202409.2278.v1

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