A broad cathepsin inhibitor blocks crystal-stimulated inflammasome-dependent and -independent inflammation, and gout arthritis

Abstract excerpt

In the disease gout, monosodium urate (MSU) crystals nucleate in joints and cause acute painful arthritis that can damage the affected joints. Similarly, the deposition of other crystals or irritant particles in tissues elicits an inflammatory response that can cause disease. These various particles stimulate macrophages to produce the proinflammatory cytokine interleukin 1β (IL-1β), which is a major driver of the...

Topics

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• Carrier Proteins
• Cathepsins
• Enzyme Inhibitors
• Inflammasomes
• Interleukin-1beta
• Macrophages
• Mice, Knockout
• NLR Family, Pyrin Domain-Containing 3 Protein

Identifiers and source

Literature Corpus work

4d3aa1ec-76e9-5f29-89d1-3901b13e2926

DOI

10.1101/2024.07.01.601464