Article

A broad cathepsin inhibitor blocks crystal-stimulated inflammasome-dependent and -independent inflammation, and gout arthritis

2024-07-03

Abstract excerpt

In the disease gout, monosodium urate (MSU) crystals nucleate in joints and cause acute painful arthritis that can damage the affected joints. Similarly, the deposition of other crystals or irritant particles in tissues elicits an inflammatory response that can cause disease. These various particles stimulate macrophages to produce the proinflammatory cytokine interleukin 1β (IL-1β), which is a major driver of the...

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Literature Corpus work: 4d3aa1ec-76e9-5f29-89d1-3901b13e2926
DOI: 10.1101/2024.07.01.601464

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