Article

Evolutionary origin of disease and complexity: A nonequilibrium thermodynamic solution

2018-06-27

Abstract excerpt

Our long-term goal was to develop realistic animal models of complex disease that are underwritten by fundamental principles. Along this path we noted a literature demonstrating that low exercise capacity is a stronger predictor of death relative to all other clinical conditions including diabetes and smoking. From this linkage we formulated the Energy Transfer Hypothesis (ETH): Variation in capacity for energy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 465014e4-f220-59d1-8b82-f4e5acb48f24
DOI: 10.1101/356493

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolutionary origin of disease and complexity: A nonequilibrium thermodynamic solutionDOI 10.1101/356493Read

Thermodynamics--old laws in medicine and complex disease.Semantic proximity Read

The nature of diseases: evolutionary, thermodynamic and historical aspects.Semantic proximity Read

Caloric Restriction, Metabolic Rate, and EntropySemantic proximity Read

Colloquium paper: bioenergetics, the origins of complexity, and the ascent of man.Semantic proximity Read

An evolutionary and genomic approach to challenges and opportunities for eliminating aging.Semantic proximity Read

Approach of evolutionary theories of ageing, stress, senescence-like phenotypes, calorie restriction and hormesis from the view point of far-from-equilibrium thermodynamics.Semantic proximity Read

Mitochondria, bioenergetics, and the epigenome in eukaryotic and human evolution.Semantic proximity Read

Escape from homeostasis.Semantic proximity Read

Thermodynamics and information in aging: why aging is not a mystery and how we will be able to make rational interventions.Semantic proximity Read

Thermodynamics and symmetry of Human Catabiosis- the present understandingSemantic proximity Read

From the stress theory of aging to energetic and evolutionary expectations for longevity.Semantic proximity Read

Entropic Systems Biology: A Novel Thermodynamic Theory for the Modernization of Traditional Chinese MedicineSemantic proximity Read