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Article

Endothelial cell apoptosis in capillary network remodeling

1 Mar 1999

Abstract excerpt

We hypothesized that the regulation of apoptosis is an important determinant of capillary network structure. Using human umbilical vein endothelial cells (HUVEC) in in vitro model systems of capillary tube formation, we initially documented that apoptosis is a prominent feature of network formation. Perturbations of integrin-matrix signaling by the administration of either colchicine or an anti-alpha(v)beta3...

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PMID: 9989782
DOI: 10.1002/(sici)1097-4652(199903)178:3<359::aid-jcp10>3.0.co;2-o

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