Article
Using rare mutations to estimate population divergence times: a maximum likelihood approach.
Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 1998
Bertorelle G, Rannala a B
Abstract excerpt
In this paper we propose a method to estimate by maximum likelihood the divergence time between two populations, specifically designed for the analysis of nonrecurrent rare mutations. Given the rapidly growing amount of data, rare disease mutations affecting humans seem the most suitable candidates for this method. The estimator RD, and its conditional version RDc, were derived, assuming that the population...
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