Article
Mitochondrial DNA mutations in Japanese patients with optic neuropathy unassociated with a mutation at nucleotide position 11,778.
Journal of human genetics - 1 Jan 1998
Matsumoto M, Hayasaka S, Hotta Y, Fujiki K, Fujimaki T, Takeda M, Ishida N, Endo S, Kanai A
Abstract excerpt
We examined for mitochondrial DNA (mtDNA) mutations at nucleotide positions(nt) 3460, 14,484, 9438, 9804, and 15,257 in ten Japanese patients with idiopathic optic neuropathy unassociated with a mutation at nt11,778. The mtDNAs were amplified by polymerase chain reaction (PCR), the products were digested with restriction enzymes, and the sizes of the fragments were analyzed on 8% polyacrylamide gel. Of the ten...
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