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EB1089, a synthetic analogue of vitamin D, induces apoptosis in breast cancer cells <i>in vivo</i> and <i>in vitro</i>

1 Nov 1998

Abstract excerpt

1. Effects of the synthetic vitamin D analogue EB1089 on indices of apoptosis in cultured human breast cancer cells and in nitrosomethylurea-induced rat mammary tumours in vivo were investigated. 2. At a dose of 0.5 microg kg(-1) body weight, EB1089 caused significant inhibition of tumour progression over the 28 day treatment period in the absence of a significant increase in serum calcium concentration. Higher...

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PMID: 9846632
DOI: 10.1038/sj.bjp.0702103

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