Biochemical and clinical pharmacology of 5-fluorouracil.

Article

Biochemical and clinical pharmacology of 5-fluorouracil.

Oncology (Williston Park, N.Y.) - 1 Oct 1998

Schilsky R L

Abstract excerpt

The cellular and clinical pharmacology of fluoropyrimidines is characterized by marked interpatient variability in tumor response and patient tolerance. Understanding the metabolic pathways followed by 5-fluorouracil (5-FU) has led to new strategies to optimize therapy with these important agents...

Topics

Administration, Oral
Antimetabolites, Antineoplastic
Biological Availability
DNA, Neoplasm
Dihydrouracil Dehydrogenase (NADP)
Fluorouracil
Humans
Neoplasms
Oxidoreductases
Phenotype

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.