Article
Innovative treatment programs against cancer. I. Ras oncoprotein as a molecular target.
Biochemical pharmacology - 1 Dec 1998
Waddick K G, Uckun F M
Abstract excerpt
Modulation of Ras function may provide a novel means by which cancer cells with oncogenic mutations can be sensitized to chemotherapeutic or radiotherapeutic regimens. Moreover, cancer cells without ras oncogene mutations can also be eliminated by compounds that interfere with the mevalonate path...
Topics
- Animals
- Cell Death
- Genes, ras
- Humans
- Models, Biological
- Mutation
- Neoplasms
- Signal Transduction
- ras Proteins