Identification of Immunodominant Regions within the C-Terminal Cell Binding Domain of Intimin α and Intimin β from Enteropathogenic Escherichia coli

Abstract excerpt

Enteropathogenic Escherichia coli (EPEC) strains are a common cause of infantile diarrhea in developing countries. EPEC strains induce a characteristic attaching and effacing (A/E) lesion on epithelial cells. A/E lesion formation requires intimin, an outer membrane adhesin protein. The cell-binding activity of intimin is localized at the C-terminal 280 amino acids of the polypeptide (Int280). So far, four...

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