Article
A common DLX3 gene mutation is responsible for tricho-dento-osseous syndrome in Virginia and North Carolina families.
Journal of medical genetics - 1 Oct 1998
Price J A, Wright J T, Kula K, Bowden D W, Hart T C
Abstract excerpt
Tricho-dento-osseous syndrome (TDO) is characterised by a variable clinical phenotype primarily affecting the hair, teeth, and bone. Different clinical features are observed between and within TDO families. It is not known whether the variable clinical features are the result of genetic heterogen...
Topics
- Abnormalities, Multiple
- Adolescent
- Adult
- Alleles
- Base Sequence
- Bone and Bones
- Chromosomes, Human, Pair 17
- Female
- Genes, Homeobox
- Genetic Heterogeneity
- Hair
- Homeodomain Proteins
- Humans
- Male
- Molecular Sequence Data
- North Carolina
- Pedigree
- Radiography