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Article

DLX3 homeodomain mutations cause tricho-dento-osseous syndrome with novel phenotypes.

Cells, tissues, organs - 1 Jan 2011

Nieminen Pekka, Lukinmaa Pirjo-Liisa, Alapulli Heikki, Methuen Mirja, Suojärvi Timo, Kivirikko Sirpa, Peltola Jaakko, Asikainen Mikko, Alaluusua Satu

Abstract excerpt

Tricho-dento-osseous syndrome (TDO) is a rare type of dominantly inherited ectodermal dysplasia so far described only in a few families and associated with 3 known mutations in the DLX3 homeobox gene. Here, we describe two families of Finnish origin that segregate features of TDO in several generations. The affected family members have sparse or curly/kinky hair at birth, markedly delayed or advanced dental...

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Source

Identifiers

PMID: 21252474
DOI: 10.1159/000322561

Genes

DLX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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DLX3 homeodomain mutations cause tricho-dento-osseous syndrome with novel phenotypes.PMID 21252474Read ↗

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A novel DLX3 mutation causes tricho-dento-osseous syndrome with abnormal enamel structure and formation.Semantic proximity Read ↗

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