Complement-Induced Expression of Chemokine Genes in Endothelium: Regulation by IL-1-Dependent and -Independent Mechanisms

Abstract excerpt

Activation of complement in the vicinity of endothelium is thought to contribute to the tissue manifestations of inflammatory and immune responses. Endothelial cells contribute to these processes in part by the elaboration of chemokines that activate various leukocytes and direct their migration into tissues. We investigated the mechanisms by which activation of complement on endothelial cell surfaces might...

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