Article
Functional analysis of peripheral blood B cells in patients with X-linked agammaglobulinemia.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1998
Nonoyama S, Tsukada S, Yamadori T, Miyawaki T, Jin Y Z, Watanabe C, Morio T, Yata J, Ochs H D
Abstract excerpt
X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disease caused by mutations of Bruton tyrosine kinase (Btk); Btk plays an essential role in the development of mature B cells. However, small numbers of B cells ("leaky B cells") are present in the peripheral blood of most XLA patien...
Topics
- Adolescent
- Adult
- Agammaglobulinaemia Tyrosine Kinase
- Agammaglobulinemia
- Animals
- Antigens, CD
- Autoimmunity
- B-Lymphocytes
- Child
- Child, Preschool
- Humans
- Mice
- Mutation
- Protein-Tyrosine Kinases
- X Chromosome