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Article

Functional analysis of peripheral blood B cells in patients with X-linked agammaglobulinemia.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1998

Nonoyama S, Tsukada S, Yamadori T, Miyawaki T, Jin Y Z, Watanabe C, Morio T, Yata J, Ochs H D

Abstract excerpt

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disease caused by mutations of Bruton tyrosine kinase (Btk); Btk plays an essential role in the development of mature B cells. However, small numbers of B cells ("leaky B cells") are present in the peripheral blood of most XLA patients. In this study, we analyzed the function of these leaky B cells obtained from XLA patients. Enough numbers of B...

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PMID: 9780159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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