Article
Hammerhead ribozymes targeted to the FBN1 mRNA can discriminate a single base mismatch between ribozyme and target.
Biochemical and biophysical research communications - 28 Aug 1998
Phylactou L A, Tsipouras P, Kilpatrick M W
Abstract excerpt
Hammerhead ribozymes are catalytic RNA molecules that can act in trans, with ribozyme and substrate being two different oligoribonucleotides with regions of complementarity. Mutations in the gene for fibrillin-1 (FBN1) cause Marfan syndrome. The majority of mutations are single-base changes, many...
Topics
- Alleles
- Base Sequence
- Binding Sites
- Cells, Cultured
- Fibrillin-1
- Fibrillins
- Humans
- In Vitro Techniques
- Marfan Syndrome
- Microfilament Proteins
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA, Antisense
- RNA, Catalytic
- RNA, Messenger