Creutzfeldt-Jakob disease with long duration and panencephalopathic lesions: molecular analysis of one case.

doi:10.1212/wnl.51.1.271

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Article

Creutzfeldt-Jakob disease with long duration and panencephalopathic lesions: molecular analysis of one case.

Neurology - 1 Jul 1998

Ghorayeb I, Series C, Parchi P, Sawan B, Guez S, Laplanche J L, Capellari S, Gambetti P, Vital C

Abstract excerpt

A 49-year-old woman presented with isolated aphasia followed by dementia and ataxia with a duration of 4 years. Histopathologically there was panencephalic involvement, status spongiosus, and kuru-type plaques. Molecular analysis showed heterozygosity at codon 129 in the prion protein (PrP) gene,...

Topics

Biopsy
Brain
Creutzfeldt-Jakob Syndrome
Female
Genotype
Humans
Kuru
Middle Aged
Nerve Fibers
Prions

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