Article
A novel mutation in the GLC1A gene causes juvenile open-angle glaucoma in 4 families from the Italian region of Puglia.
Archives of ophthalmology (Chicago, Ill. : 1960) - 1 Jun 1998
Angius A, De Gioia E, Loi A, Fossarello M, Sole G, Orzalesi N, Grignolo F, Cao A, Pirastu M
Abstract excerpt
BACKGROUND: Primary open-angle glaucoma encompasses a complex of potentially blinding ocular diseases characterized by a normal-appearing angle of the anterior chamber, a characteristic degeneration of the optic nerve with resultant typical visual field defects, and usually, an elevated intraocul...
Topics
- Adolescent
- Adult
- Child
- Cytoskeletal Proteins
- DNA Mutational Analysis
- DNA Primers
- Exons
- Eye Proteins
- Female
- Genetic Linkage
- Glaucoma, Open-Angle
- Glycoproteins
- Humans
- Italy
- Male
- Middle Aged
- Mutation
- Pedigree